Biomarker Discovery

Metabolomics for Biomarker Discovery

Metabolomics is the study of the small molecule biochemistry of an organism. The goal is to understand the metabolic state of a subject by extracting, identifying and quantifying all of the small molecule compounds (for example, metabolites) in a biological sample. Since it is based upon biochemistry and provides a measurement of the biological status of an organism, metabolomics provides a pow...

Network-Guided Biomarker Discovery

Identifying measurable genetic indicators (or biomarkers) of a specific condition of a biological system is a key element of precision medicine. Indeed it allows to tailor diagnostic, prognostic and treatment choice to individual characteristics of a patient. In machine learning terms, biomarker discovery can be framed as a feature selection problem on whole-genome data sets. However, classical...

SILAC for biomarker discovery.

SILAC has been employed in MS-based proteomics for nearly a decade. This method is based on cells in culture metabolically incorporating isotope-coded essential amino acids and allows the quantification of global protein populations to identify characteristic changes. Variations of this technique developed over the years allow the application of SILAC not only to cell culture derived samples bu...

BiOmarkEr DiscOvEry mEchanisms

Biomarker discovery and validation.

Currently available biomarkers, such as those used to diagnose myocardial infarction (e.g., cardiac troponins), were identified in the course of targeted physiologic studies. Similarly, basic investigation of diseases has largely been characterized by studies of isolated molecules in cellular systems. Advances in genomics technologies, however, are beginning to permit characterization of global...